One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
Multiplex genome engineering using CRISPR/Cas systems
Dr. Feng Zhang
Department of Brain and Cognitive Sciences
Department of Biological Engineering
Massachusetts Institute of Technology
October 16, 2013 - 4:00pm
Host: Dr. Stephane Angers and Dr. David R. Hampson
Pharmacy Building Auditorium PB-B250
CIHR Biological Therapeutics Training Program Seminar
The Biological Therapeutics Training Program is proud to announce its sponsorship and participation in the 2013 Neurobiology Meeting, taking place at the University of Toronto in June, hosted by Dr. Oliver Ernst (Biochemistyr Department) and featuring a keynote address by Brian Kobilka, 2012 Nobel Laureate.
Biological Therapeutic Meetings, University of Toronto, May 2-3, 2013
In Spring 2013, the Biotherapeutics Program will hold two symposia on consecutive days on
1) The Blood Brain Barrier, and
2) Mechanisms of distribution of macromolecules and nanoparticle in tissues
Click here to view full program
Tumor-penetrating transport of cancer drugs is activated by the peptide iRGD (multicolored ring), which binds to integrin receptors (blue and yellow) in tumor blood vessels, and is subsequently cleaved. The cleaved peptide then binds to neuropilin-1 receptors (purple), activating a transport system that carries coadministered drugs, such as antibodies (green), deeper into tumor tissue.
Image: Peter Allen/University of California, Santa Barbara
Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs, Kazuki N. Sugahara, et al.
Science 328, 1031 (2010);